In a new Perspective published in Cells, researchers in the TIME Lab explore the indirect and direct roles of tumor mechanical stresses on canonical immune evasion pathways - EMT and autophagy - and immunotherapy resistance. Led by Killian Onwudiwe and Julian Najera along with Saeed Siri, this publication is part of a special issue on "Cellular integrity under mechanical stress," and it identifies gaps in the field that need to be addressed in order to causally confirm these mechano-immunological links.