In a new publication out today in Biomechanics and Modeling in Mechanobiology, the TIME Lab presents a new mathematical model of the impact of brain tumor growth-induced forces on glymphatic structure and function within the brain parenchyma, using experimental parameters from the literature and a combination of electrical analog modeling and finite element analysis. Led by our postdoctoral fellow, Saeed Siri, with help from our graduate student, Alice Burchett, our model predicts diminished fluid flow within brain parenchymal glymphatic units with i) increasing tumor size, ii) closer proximity of glymphatic units to tumors, and iii) poorer coverage of glymphatic units by astrocytes. While glymphatics have been under close scrutiny for other conditions (e.g., neurodegenerative diseases, traumatic brain injuries), much remains to be understood in the context of brain cancer. Further experimental and computational work in this area will continue to shed light on the bidirectional impact of glymphatics and brain tumors.