Publications
Pre-prints
Burchett A.A., Siri S., Li J., Lu X., and Datta M.# “Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response," submitted. Preprint available on bioRxiv. (# = corresponding author.)
Shanmugarajan K., Lee S., Subudhi S., Kumar A.S., Amoozgar Z., Posada J., Lindeman N., Lei P., Duquette M., Roberge S., Huang P., Andersson P., Datta M., Munn L.L., Fukumura D., and Jain R.K. “Wnt inhibition alleviates resistance to immune checkpoint blockade therapy in glioblastoma,” submitted. Preprint available on Research Square.
Original Research
Onwudiwe K.*, Najera J.*, Holen L., Burchett A.A., Rodriguez D., Zarodniuk M., Siri S., and Datta M.# “Single-cell mechanical analysis reveals viscoelastic similarities in normal and neoplastic brain cells,” Biophysical Journal, E-pub ahead of print: https://www.cell.com/biophysj/fulltext/S0006-3495(24)00215-7. (* = equal contributions; # = corresponding author.)
Datta M.*,#, Via L.E.*, Dartois V.*, Weiner D.M., Zimmerman M., Kaya F., Walker A.M., Fleegle J.D., Raplee I.D., McNinch C., Zarodniuk M., Kamoun W.S., Yue C., Kumar A.S., Subudhi S., Xu L., Barry C.E., and Jain R.K.#“Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits,” Proceedings of the National Academy of Sciences, E-pub ahead of print: https://www.pnas.org/doi/abs/10.1073/pnas.2321336121. (* = equal contributions; # = corresponding authors.)Featured in Notre Dame News, EurekAlert!, Medical Xpress, Science Daily, and Genetic Engineering & Biotechnology News.
Datta M.#, Kennedy M., Siri S., Via L.E., Baish J.W., Xu L., Dartois V., Barry C.E., and Jain R.K.# “Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas,” PLoS Computational Biology, E-pub ahead of print: https://doi.org/10.1371/journal.pcbi.1011847. (# = corresponding authors.)
Morsby J.J., Zhang Z., Burchett A.A., Datta M.#, and Smith B.D.# (2024) “Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids,” Chemical Science, E-pub ahead of print: https://doi.org/10.1039/D3SC06058F. (# = corresponding authors.)
Chen J., Amoozgar Z., Liu X., Aoki S., Liu Z., Shin S., Matsui A., Pu Z., Lei P., Datta M., Zhu L., Ruan Z., Shi L., Staiculescu D., Inoue K., Munn L.L., Fukumura D., Huang P. Bardeesy N., Ho W.J., Jain R.K., and Duda D.G. (2024) “Reprogramming intrahepatic cholangiocarcinoma immune microenvironment by chemotherapy and CTLA-4 blockade enhances anti-PD1 therapy,” Cancer Immunology Research, E-pub ahead of print: https://doi.org/10.1158/2326-6066.CIR-23-0486.
Iorgulescu J.B., Ruthen N.*, Ahn R.*, Panagioti E.*, Gokhale P.*, Neagu M., Speranza M.C., Eschle B.K., Soroko K.M., Piranlioglu R., Datta M., Krishnan S., Yates K.B., Baker G., Jain R.K., Suvà M.L., Neuberg D., White F.M., Chiocca E.A., Freeman G.J., Sharpe A.H., Wu C.J., and Reardon D.A. (2023) “Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model,” Frontiers in Immunology, E-pub ahead of print: https://doi:10.3389/fimmu.2023.1297932.
Zarodniuk M., Steele A., Lu X., Li J., and Datta M.# “CNS tumor stroma transcriptomics identify perivascular fibroblasts as predictors of immunotherapy resistance in glioblastoma patients,” npj Genomic Medicine, E-pub ahead of print: https://www.nature.com/articles/s41525-023-00381-w. (# = corresponding author.)
Holen L.*, Onwudiwe K.*, Najera J., Zarodniuk M., Obayemi J.D., Soboyejo W.O., and Datta M.# (2023) “Shear assay protocol for the determination of single-cell material properties,” Journal of Visualized Experiments, E-pub ahead of print: https://www.jove.com/t/65333/shear-assay-protocol-for-determination-single-cell-material. (* = equal contributions; # = corresponding author.)
Dong X.*, Ren J.*, Amoozgar Z., Lee S., Datta M., Roberge S., Duquette M., Fukumura D., and Jain R.K. (2023) “Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice,” Journal for ImmunoTherapy of Cancer, 11: e005583, E-pub ahead of print: https://jitc.bmj.com/content/11/3/e005583.
Datta M.#, Chatterjee S., Perez E.M., Gritsch S., Roberge S., Duquette M., Chen I.X., Naxerova K., Kumar A.S., Ghosh M., Emblem K.E., Ng M.R., Ho. W.W., Kumar P., Krishnan S., Dong X., Speranza M.C., Neagu M.R., Reardon D.A., Sharpe A.H., Freeman G.J., Suva M.L.#, Xu L.#, Jain R.K.# (2023) “Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma,” E-pub ahead of print: https://www.pnas.org/eprint/MP69MI2GBHTY9VJKDSBQ/full. (# = corresponding author(s).)
Ho W.W., Gomes-Santos I.L., Talele N.P., Aoki S., Datta M., Kawagushi K., Ren J., Liu H. Chen I.X., Nojiri T., Chatterjee S., Zhao Y., Millar D.G., Clark J.W., Cobbold M., Pittet M.J., Fukumura D., and Jain R.K. (2021) “Orthotopic liver metastatic mouse models of mismatch repair-proficient colorectal cancer predict clinical inefficacy of immune checkpoint blockade,” Proceedings of the National Academy of Sciences, E-pub ahead of print: https://www.pnas.org/content/118/45/e2105323118.
Wu L., Vasilijic S., Sun Y., Chen J., Landegger L.D., Zhang Y., Zhou W., Ren J., Yin Z., Ho W.W., Zhang N., Gao X., Datta M., Early S., Brown A., Sagers J.E., Muzikansky A., Zhang L., Stemmer- Rachamimov A., Plotkin S.R., Jain R.K., Stankovic K.M., and Xu L. (2021) “Losartan prevents tumor-induced hearing loss and augments radiation efficacy by normalizing the tumor microenvironment in NF2 schwannoma models,” Science Translational Medicine, E-pub ahead of print: https://stm.sciencemag.org/content/13/602/eabd4816.abstract. Featured in EurekAlert, Scienmag, Medical Xpress, GEN, and Hearing Health & Technology Matters.
Nia H.T.*, Datta M.*, Seano G.*, Ho W.W., Roberge S., Huang P., Munn L.L. and Jain R.K. (2020) “In vivo compression and imaging in mouse brain to measure the effects of solid stress,” Nature Protocols, 15: 2021-2340. (* = equal contributions.) Featured in Nature Community.
Flores-Toro J.A., Luo D., Gopinath A., Sarkisian M., Campbell J.J., Charo I.F., Singh R., Schall T.J., Datta M., Jain R.K., Mitchell D.A., and Harrison J.K. (2019) “CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas,” Proceedings of the National Academy of Sciences, 117: 1129-1138. Featured in Medical Xpress and EurekAlert.
Shigeta K*., Datta M.*, Hato T.*, Kitahara S.*, Chen I.X., Mamessier E. Matsui A., Ramijiawan R.R., Aoki S., Ochiai H., Bardeesy N., Huang P., Cobbold M., Zhu A.X., Jain R.K., and Duda D.G. (2019) “Dual programmed death receptor-1 and vascular endothelial growth factor receptor-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC,” Hepatology, 7: 1247-1261. (* = equal contributions.)
Zhao Y. Cao J., Melamed A., Worley M., Gockley A., Jones D., Nia H.T., Zhang Y., Stylianopoulos T., Kumar A.S., Mpekris F., Datta M., Sun Y., Wu L., Gao X., Yeku O., del Carmen M., Spriggs D.R., Jain R.K., and Xu L. (2019) “Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma,” Proceedings of the National Academy of Science, 116: 2210-2219. Featured in New England Journal of Medicine Journal Watch, Medical News Bulletin, Ovarian Cancer News Today, and Medical Xpress.
Seano G.*, Nia H.T.*, Emblem, K.E.*, Datta M., Ren J., Krishnan S., Kloepper J., Pinho M.C., Ho W.W., Ghosh M., Askoxylakis V., Ferraro G.B., Riedemann L., Gerstner E.R., Batchelor T.T., Wen P.Y., Lin N.U., Grodzinksy A.J., Fukumura D., Huang P., Basish J.W., Padera T.P., Munn L.L., and Jain R.K. (2019) “Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium,” Nature Biomedical Engineering, 3: 230-245. (* = equal contributions.) Featured in Nature Research Bioengineering Community, Neuroscience News, EurekAlert, and Medical Xpress.
Arvanitis C.*, Askoxylakis V.*, Guo Y., Datta M., Kloepper J., Ferraro G.B., Bernabeu M.O., Fukumura D., McDannold N., and Jain R.K. (2018) “Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption,” Proceedings of the National Academy of Sciences, 115: E8717-E8726. (* = equal contributions.) Featured in Technology.org, EurekAlert and Medical Xpress.
Nia H.T.*, Datta M.*, Seano G., Munn L.L., and Jain R.K. (2018) “Quantifying solid stress and elastic energy from excised or in situ tumors,” Nature Protocols 13: 1091-1105. (* = equal contributions.)
Carr J.A., Franke D., Caram J.R., Perkinson C.F., Saif M., Askoxylakis V., Datta M., Fukumura D., Jain R.K., Bawendi M.G., and Bruns O.T. (2018) “Shortwave Infrared Fluorescence Imaging with the Clinically Approved Near-Infrared Dye Indocyanine Green,” Proceedings of the National Academy of Science 115: 4465-4470. Featured in MIT News and SciTech Daily.
Zhang N., Chen J., Ferraro G., Wu L., Datta M., Jain R.K., Plotkin S.R., Stemmer-Rachamimov A., and Xu L. (2017) “Anti-VEGF treatment improves neurological function in tumors of the nervous system,” Experimental Neurology 299: 326-333.
Levin V.A., Chan J., Datta M., Yee, J.L., and Jain R.K. (2017) “Effect of Angiotensin System Inhibitors on Survival in Newly Diagnosed Glioma Patients and Recurrent Glioblastoma Patients Receiving Chemotherapy and/or Bevacizumab,” Journal of Neuro-Oncology 134: 325-330. Featured in Practice Update.
Nia H.T., Seano G., Liu H., Datta M., Jones D., Rahbari N., Incio J., Chauhan V.P., Jung K., Martin J.D., Askoxylakis V., Padera T.P., Fukumura D., Boucher Y., Hornicek F.J., Grodzinsky A.J., Baish J.W., Munn L.L., and Jain R.K. (2016) “Solid stress and elastic energy as measures of tumor mechanopathology,”Nature Biomedical Engineering 1: 1-11. Featured in Nature News and Views, Nature Reviews Clinical Oncology, Harvard Medical School News & Research, Medical Xpress, and EurekAlert.
Peterson T.E.*, Kirkpatrick N.D.*, Huang Y.*, Farrar C., Marijt K.A., Kloepper J., Datta M., Amoozgar Z., Seano G., Jung K., Kamoun W.S., Vardam T., Snuderl M., Goveia J., Chatterjee S., Batista A., Muzikansky A., Leow C.C., Xu L., Batchelor T.T., Duda D.G., Fukumura D., and Jain R.K. (2016) “Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages,” Proceedings of the National Academy of Sciences 113: 4470-4475. (* = equal contributions.) Featured in Science Daily.
Kloepper J.*, Riedemann L.*, Amoozgar Z.*, Seano G., Susek K.H., Yu V., Dalvie N., Amelung R.L., Datta M., Song J.W., Askoxylakis V., Taylor J.W., Lu-Emerson C., Batista A., Kirkpatrick N.D., Snuderl M., Muzikansky A., Stubenrauch K.G., Wakimoto H., Xu L., Munn L.L., Duda D.G., Fukumura D., Batchelor T.T., and Jain R.K. (2016) “Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival,” Proceedings of the National Academy of Sciences 113: 4476-4481. (* = equal contributions.) Featured in Science Daily.
Datta M., Via L.E., Chen W., Baish J.W., Xu L., Barry C.E., and Jain R.K. (2016) “Mathematical Model of Oxygen Transport in Tuberculosis Granulomas,” Annals of Biomedical Engineering 44: 863-872.
Datta M.*, Via L.E.*, Kamoun W.S.*, Liu C., Chen W., Seano G. Weiner D.M., Schimel D., England K., Martin, J.D., Gao X., Xu L., Barry C.E., and Jain R.K. (2015) “Anti-VEGF treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery,” Proceedings of the National Academy of Sciences 112: 1827-1832. (* = equal contributions.) Featured in Nature Reviews Drug Discovery, PBS NOVA Next, and EurekAlert.
Datta M., Jackson M.D., and Datta R. (2011) “Of Mice and Men: Their Diet, Metabolism, and Weight Change,” Chemical Engineering Science 66: 4510-4520.
Reviews/Book Chapters
Najera J., Rosenberger M.R., and Datta M.# (2023) “Atomic force microscopy methods to measure tumor mechanical properties,” Cancers, 15: 3285.
Zhang S.*, Regan K.*, Najera J.*, Chu V., Grinstaff M.W., Datta M.#, and Nia H.T.# “The peritumor microenvironment: physics and immunity,” Trends in Cancer, E-pub ahead of print: https://authors.elsevier.com/a/1h1a98Z12yTuSQ. (* = equal contributions)
Onwudiwe K.*, Najera J.*, Siri S., and Datta M.# (2022) "Do tumor mechanical stresses promote cancer immune escape?" Cells, 11: 3840. (* = equal contributions.)
Onwudiwe K., Burchett A.A., and Datta M.# (2022) “Mechanical and metabolic interplay in the brain metastatic microenvironment,” Frontiers in Oncology, E-pub ahead of print: https://www.frontiersin.org/articles/10.3389/fonc.2022.932285/full.
Datta M., Coussens L.M., Nishikawa H., Hodi F.S., and Jain R.K. (2019) “Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies,” American Society of Clinical Oncology Educational Book, 39: 165-174. Featured in Medpage Today.
Zhang N., Gao X., Zhao Y., Datta M., Liu P., and Xu, L. (2016) “Rationally combining anti-VEGF therapy with radiation in NF2 schwannoma,” Journal of Rare Diseases Research & Treatment 1: 51-55.
Spotlights/Interviews
Datta M. (2022) “Studying the tumor microenvironment under pressure,” Immuno-Oncology Insights, 3: 339-344.