Datta M.#, Chatterjee S., Perez E.M., Gritsch S., Roberge S., Duquette M., Chen I.X., Naxerova K., Kumar A.S., Ghosh M., Emblem K.E., Ng M.R., Ho. W.W., Kumar P., Krishnan S., Dong X., Speranza M.C., Neagu M.R., Reardon D.A., Sharpe A.H., Freeman G.J., Suva M.L.#, Xu L.#, Jain R.K.# “Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma,” (# = corresponding author(s).) Preprint available on bioRiv.



Ho W.W., Gomes-Santos I.L., Talele N.P., Aoki S., Datta M., Kawagushi K., Ren J., Liu H. Chen I.X., Nojiri T., Chatterjee S., Zhao Y., Millar D.G., Clark J.W., Cobbold M., Pittet M.J., Fukumura D., and Jain R.K. (2021) “Orthotopic liver metastatic mouse models of mismatch repair-proficient colorectal cancer predict clinical inefficacy of immune checkpoint blockade,” Proceedings of the National Academy of Sciences, E-pub ahead of print:


Wu L., Vasilijic S., Sun Y., Chen J., Landegger L.D., Zhang Y., Zhou W., Ren J., Yin Z., Ho W.W., Zhang N., Gao X., Datta M., Early S., Brown A., Sagers J.E., Muzikansky A., Zhang L., Stemmer- Rachamimov A., Plotkin S.R., Jain R.K., Stankovic K.M., and Xu L. (2021) “Losartan prevents tumor-induced hearing loss and augments radiation efficacy by normalizing the tumor microenvironment in NF2 schwannoma models,” Science Translational Medicine, E-pub ahead of print: Featured in EurekAlert, Scienmag, Medical Xpress, GEN, and Hearing Health & Technology Matters


Nia H.T.*, Datta M.*, Seano G.*, Ho W.W., Roberge S., Huang P., Munn L.L. and Jain R.K. (2020) “In vivo compression and imaging in mouse brain to measure the effects of solid stress,” Nature Protocols, 15: 2021-2340. (* = equal contributions.) Featured in Nature Community.


Flores-Toro J.A., Luo D., Gopinath A., Sarkisian M., Campbell J.J., Charo I.F., Singh R., Schall T.J., Datta M., Jain R.K., Mitchell D.A., and Harrison J.K. (2019) “CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas,Proceedings of the National Academy of Sciences, 117: 1129-1138. Featured in Medical Xpress and EurekAlert.


Shigeta K*., Datta M.*, Hato T.*, Kitahara S.*, Chen I.X., Mamessier E. Matsui A., Ramijiawan R.R., Aoki S., Ochiai H., Bardeesy N., Huang P., Cobbold M., Zhu A.X., Jain R.K., and Duda D.G. (2019) “Dual programmed death receptor-1 and vascular endothelial growth factor receptor-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC,” Hepatology, 7: 1247-1261. (* = equal contributions.)


Zhao Y. Cao J., Melamed A., Worley M., Gockley A., Jones D., Nia H.T., Zhang Y., Stylianopoulos T., Kumar A.S., Mpekris F., Datta M., Sun Y., Wu L., Gao X., Yeku O., del Carmen M., Spriggs D.R., Jain R.K., and Xu L. (2019) “Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma,” Proceedings of the National Academy of Science, 116: 2210-2219. Featured in New England Journal of Medicine Journal Watch, Medical News Bulletin, Ovarian Cancer News Today, and Medical Xpress.     


Seano G.*, Nia H.T.*, Emblem, K.E.*, Datta M., Ren J., Krishnan S., Kloepper J., Pinho M.C., Ho W.W., Ghosh M., Askoxylakis V., Ferraro G.B., Riedemann L., Gerstner E.R., Batchelor T.T., Wen P.Y., Lin N.U., Grodzinksy A.J., Fukumura D., Huang P., Basish J.W., Padera T.P., Munn L.L., and Jain R.K. (2019) “Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium,” Nature Biomedical Engineering, 3: 230-245. (* = equal contributions.) Featured in Nature Research Bioengineering Community, Neuroscience News, EurekAlert, and Medical Xpress.

Arvanitis C.*, Askoxylakis V.*, Guo Y., Datta M., Kloepper J., Ferraro G.B., Bernabeu M.O., Fukumura D., McDannold N., and Jain R.K. (2018) “Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption,” Proceedings of the National Academy of Sciences, 115: E8717-E8726. (* = equal contributions.) Featured in, EurekAlert and Medical Xpress.


Nia H.T.*, Datta M.*, Seano G., Munn L.L., and Jain R.K. (2018) “Quantifying solid stress and elastic energy from excised or in situ tumors,” Nature Protocols 13: 1091-1105. (* = equal contributions.)


Carr J.A., Franke D., Caram J.R., Perkinson C.F., Saif M., Askoxylakis V., Datta M., Fukumura D., Jain R.K., Bawendi M.G., and Bruns O.T. (2018) “Shortwave Infrared Fluorescence Imaging with the Clinically Approved Near-Infrared Dye Indocyanine Green,” Proceedings of the National Academy of Science 115: 4465-4470. Featured in MIT News and SciTech Daily.


Zhang N., Chen J., Ferraro G., Wu L., Datta M., Jain R.K., Plotkin S.R., Stemmer-Rachamimov A., and Xu L. (2017) “Anti-VEGF treatment improves neurological function in tumors of the nervous system,” Experimental Neurology 299: 326-333.


Levin V.A., Chan J., Datta M., Yee, J.L., and Jain R.K. (2017) “Effect of Angiotensin System Inhibitors on Survival in Newly Diagnosed Glioma Patients and Recurrent Glioblastoma Patients Receiving Chemotherapy and/or Bevacizumab,” Journal of Neuro-Oncology 134: 325-330. Featured in Practice Update.


Nia H.T., Seano G., Liu H., Datta M., Jones D., Rahbari N., Incio J., Chauhan V.P., Jung K., Martin J.D., Askoxylakis V., Padera T.P., Fukumura D., Boucher Y., Hornicek F.J., Grodzinsky A.J., Baish J.W., Munn L.L., and Jain R.K. (2016) “Solid stress and elastic energy as measures of tumor mechanopathology,”Nature Biomedical Engineering 1: 1-11. Featured in Nature News and Views, Nature Reviews Clinical Oncology, Harvard Medical School News & Research, Medical Xpress, and EurekAlert.


Peterson T.E.*, Kirkpatrick N.D.*, Huang Y.*, Farrar C., Marijt K.A., Kloepper J., Datta M., Amoozgar Z., Seano G., Jung K., Kamoun W.S., Vardam T., Snuderl M., Goveia J., Chatterjee S., Batista A., Muzikansky A., Leow C.C., Xu L., Batchelor T.T., Duda D.G., Fukumura D., and Jain R.K. (2016) “Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages,” Proceedings of the National Academy of Sciences 113: 4470-4475. (* = equal contributions.) Featured in Science Daily.


Kloepper J.*, Riedemann L.*, Amoozgar Z.*, Seano G., Susek K.H., Yu V., Dalvie N., Amelung R.L., Datta M., Song J.W., Askoxylakis V., Taylor J.W., Lu-Emerson C., Batista A., Kirkpatrick N.D., Snuderl M., Muzikansky A., Stubenrauch K.G.,  Wakimoto H., Xu L., Munn L.L., Duda D.G., Fukumura D., Batchelor T.T., and Jain R.K. (2016) “Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival,” Proceedings of the National Academy of Sciences 113: 4476-4481. (* = equal contributions.) Featured in Science Daily.


Datta M., Via L.E., Chen W., Baish J.W., Xu L., Barry C.E., and Jain R.K. (2016) “Mathematical Model of Oxygen Transport in Tuberculosis Granulomas,” Annals of Biomedical Engineering 44: 863-872.


Datta M.*, Via L.E.*, Kamoun W.S.*, Liu C., Chen W., Seano G. Weiner D.M., Schimel D., England K., Martin, J.D., Gao X., Xu L., Barry C.E., and Jain R.K. (2015) “Anti-VEGF treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery,” Proceedings of the National Academy of Sciences 112: 1827-1832. (* = equal contributions.) Featured in Nature Reviews Drug Discovery, PBS NOVA Next, and EurekAlert.


Datta M., Jackson M.D., and Datta R. (2011) “Of Mice and Men: Their Diet, Metabolism, and Weight Change,” Chemical Engineering Science 66: 4510-4520.

Reviews/Book Chapters 


Onwudiwe K., Burchett A.A., and Datta M.# (2022) “Mechanical and metabolic interplay in the brain metastatic microenvironment,” Frontiers in Oncology, E-pub ahead of print:


Datta M., Coussens L.M., Nishikawa H., Hodi F.S., and Jain R.K. (2019) “Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies,” American Society of Clinical Oncology Educational Book, 39: 165-174. Featured in Medpage Today.


Zhang N., Gao X., Zhao Y., Datta M., Liu P., and Xu, L. (2016) “Rationally combining anti-VEGF therapy with radiation in NF2 schwannoma,” Journal of Rare Diseases Research & Treatment 1: 51-55.



Datta M. (2022) “Studying the tumor microenvironment under pressure,” Immuno-Oncology Insights, 3: 339-344.